A fundamental goal of neuroscience has always been to deduce the brain systems that underlie such basic drives as hunger, thirst and sex. In 1956 the well-known physiologist James Olds wrote an article for Scientific American, called “Pleasure Centers in the Brain,” that described how a rat kept without food for a day was lured down a platform by a tasty meal. En route to dinner, it received a pleasurable electric shock. The rat never showed up for mealtime, instead choosing to delight in the arousal. With the optimism characteristic of that era, Olds concluded that stimulation experiments would lead to an understanding of neural functioning that would allow “one drug that will raise or lower thresholds in the hunger system, another for the sex-drive system, and so forth.”
Fifty years later the promise of Olds’s vision has yet to fully materialize. Better drugs are needed to suppress appetite and spark sexual desire. But fascination has grown in recent years with taking Olds’s more direct route of stimulating the central nervous system.
[More]source: sciam
