1.Narco Analysis
In criminal psychology, these exists one area which uses so-called truth drug to elicit true answer from criminals. And administration of such drugs are called narco analysis( narco analysis method of interrogation, in chinese it's called"
麻醉分析讯问法"）
. For more info, go to wikipedia.
2.Compusense sense labratory solution
According to one job description at 51job, Compusense is a commercial software needed while establishing labratories of taste. In google scholar, I've found no psychological researcher with compusense specialty. Interesting.
3.BPS certification
British Psychological Society may be as large as the renowned American Psychological Association. It has a variety of certifications of psychological assessments(level A, level B).Among psychological best practices, SHL specialises psychological assessment. In fact, SHL is a UK-based company. So this fact tells me that if you want to join SHL, you must first get certification from BPS. It's the same to engineering psychology and user centered design. Human Factors International(HFI) is a best practice in this field and it business is mainly focused on certification and training.
2010年7月11日星期日
2010年5月17日星期一
Google's Adsense and Psycholinguistics
Adsense is one of google's profitable tools. Its tech is based on Applied Semantics acquired（Chinese：收购） by Google in 2003. Applied Semantics uses a tech called CIRCA(patented information maybe seen at here and here). In its tech's introduction, it tells it's based on Cognitive Psychologist George Miller's Wordnet. This person may be called the founder or key role in modern cognitive perspective to human psy. His main contribution is in language and semantics(psycholinguistics, which uses cognitive perspective to study language).
Today, Wordnet has been used widely in Natural Language Processing(NLP). Other important resources for NLP(English) maybe British National Corpus. As for Chinese, it's Penn Treebank Project. Tks for Alex00zee at douban for directions.
This phenomenon is very surprising cauz google's horizon on science from several cutting edge and well flourished scientific disciplines. Why not to study the spread of science and decide your next M&A(merge and acquisition, in fact large companies often buys tech advanced small companies to keep their competence)?
Next phase, I will cover human 2.0 and one of google's geek ambition: technology singularity, transhumanism.
Indeed, with NBIC convergence and neuroengineering(neuroinformatics), I feel I've become a transhumanist. Maybe one day I'll join transhumanism.org.
Today, Wordnet has been used widely in Natural Language Processing(NLP). Other important resources for NLP(English) maybe British National Corpus. As for Chinese, it's Penn Treebank Project. Tks for Alex00zee at douban for directions.
This phenomenon is very surprising cauz google's horizon on science from several cutting edge and well flourished scientific disciplines. Why not to study the spread of science and decide your next M&A(merge and acquisition, in fact large companies often buys tech advanced small companies to keep their competence)?
Next phase, I will cover human 2.0 and one of google's geek ambition: technology singularity, transhumanism.
Indeed, with NBIC convergence and neuroengineering(neuroinformatics), I feel I've become a transhumanist. Maybe one day I'll join transhumanism.org.
2010年3月6日星期六
About vocal DOD tech：A summary
Vocal DOD tech means using vocal analyser to analyse psychological factors of sound including tone, loudness, musical quality.
According to wiki, vocal analyser DOD tech is named "Voice Stress Analysis" or specifically "Layered Voice Test"(also from wiki). It is mainly used in airports and some insurance companies to detect lying. However, Deception blog has lots of articles indicating it doesn't work.
Unfortunately, I haven't found any other test equipments so famous like polygraph to analyse sound's psychfactor and detect lies. But we do see Lock("Lie to Me") used unfamiliar device to decompose subject's voice. What's that? I guess it won't be voice stress analysis software "X13-VSA".
Anyway, consulting expert might be a better choice. I've found one in Chine. Her name is Cuiling Zhang and her book(in Chinese) has lots of details of vocal lie detection esp. in Chapter 2.
According to wiki, vocal analyser DOD tech is named "Voice Stress Analysis" or specifically "Layered Voice Test"(also from wiki). It is mainly used in airports and some insurance companies to detect lying. However, Deception blog has lots of articles indicating it doesn't work.
Unfortunately, I haven't found any other test equipments so famous like polygraph to analyse sound's psychfactor and detect lies. But we do see Lock("Lie to Me") used unfamiliar device to decompose subject's voice. What's that? I guess it won't be voice stress analysis software "X13-VSA".
Anyway, consulting expert might be a better choice. I've found one in Chine. Her name is Cuiling Zhang and her book(in Chinese) has lots of details of vocal lie detection esp. in Chapter 2.
2009年12月31日星期四
Can monkeys help your investment?
Quote "This article mainly focuses on the debate on monkey's investment ability and its anecdotes. I've sent it to my friends in finance department but no reply, and to 52brain.com neuroeconomics forum also no rely. What's wrong? The research made by psychologist is interesting and it may cover such topics like the book "Nudge" & behavioral portfolio (company) by famous decision making research scientist Thaler. Huge gap, huh?"
----------------------------
In "Quirkology", prof. Richard Wiseman mentioned two famous/infamous psychological experiment about monkey like portfolio on stocks. In both two experiments, one invested by a little girl via picking up scraps of paper and another by a champzine called Aula(in Chinese edition, "奥拉") via dart throwing, so called random selections beat financial professionals.
I was surprised at that time. How could this happen? As I know, financial professionals use logical/statistical mathematical tools analyse the stock information and gain market insights. Among them, Black-Scholes Option Pricing model may be the most widely used one. And this field is not magic but has a formal academic name called "Econophysics"(see this book in Chinese). In this industry, Renaissance hedge fund may be the most famous company based on such models and gain great market success as well. Most of its employees are mathematical graduates from top US universities(however they lack Wall Street working background, and Wall Street is the famous place where top financial companies locate). They call themselves "Quants"(in Chinese 宽客）(see this book in Chinese).
Based on these facts, I think it isn't possible for them (those who use rigid mathematical models like Renaissance, not those in Wall Street) to lose. As for those in Wall street, indeed, Wall Street Journal established a contest between random selection of stocks and those financial professionals from 1988 to 2002. It is to respond prof. Burton Malkiel's "A Random Walk Down Wall Street". The contest ended without delaration of any winner. More details can be found here and here. The 14 contest's outcome seems interesting (the graph can be found here).
Though professionals beat the "monkeys" (dart selection), the percentages they outperform over them aren't larger enough.
I hope these words will help readers and myself as well:). For more info, pls google for keywords
"飞镖选股法", "darts portfolio" and "monkey business".
--------------------
Term explanation
- In English, monkey business originally means fraud business like Bernard Madoff but here it is really made by monkeys or random dart throwing.
----------------------------
In "Quirkology", prof. Richard Wiseman mentioned two famous/infamous psychological experiment about monkey like portfolio on stocks. In both two experiments, one invested by a little girl via picking up scraps of paper and another by a champzine called Aula(in Chinese edition, "奥拉") via dart throwing, so called random selections beat financial professionals.
I was surprised at that time. How could this happen? As I know, financial professionals use logical/statistical mathematical tools analyse the stock information and gain market insights. Among them, Black-Scholes Option Pricing model may be the most widely used one. And this field is not magic but has a formal academic name called "Econophysics"(see this book in Chinese). In this industry, Renaissance hedge fund may be the most famous company based on such models and gain great market success as well. Most of its employees are mathematical graduates from top US universities(however they lack Wall Street working background, and Wall Street is the famous place where top financial companies locate). They call themselves "Quants"(in Chinese 宽客）(see this book in Chinese).
Based on these facts, I think it isn't possible for them (those who use rigid mathematical models like Renaissance, not those in Wall Street) to lose. As for those in Wall street, indeed, Wall Street Journal established a contest between random selection of stocks and those financial professionals from 1988 to 2002. It is to respond prof. Burton Malkiel's "A Random Walk Down Wall Street". The contest ended without delaration of any winner. More details can be found here and here. The 14 contest's outcome seems interesting (the graph can be found here).
Though professionals beat the "monkeys" (dart selection), the percentages they outperform over them aren't larger enough.I hope these words will help readers and myself as well:). For more info, pls google for keywords
"飞镖选股法", "darts portfolio" and "monkey business".
--------------------
Term explanation
- In English, monkey business originally means fraud business like Bernard Madoff but here it is really made by monkeys or random dart throwing.
2009年8月16日星期日
NeuroFocus 通过收购 Neuroco 进驻英国及欧洲市场
世界领先的神经测试公司收购在迅速发展的脑波市场研究领域处于领先地位的英国公司
加州伯克利2009年3月12日电 /美通社亚洲/ -- 迅速发展的神经营销学领域的世界领导者 NeuroFocus 宣布，该公司已经签署了一份收购 Neuroco 的协议。这一举动表明了该公司全球扩张的下一步计划，在此之前，NeuroFocus 已经在美国得到了迅速发展，并通过在日本和韩国等几个重要亚洲国家获得新的大客户拓展了自己在亚洲的业务。
NeuroFocus 和 Neuroco 均为未上市公司。此次收购的条款尚未公布。Neuroco 今后将作为NeuroFocus Europe 运营。
总部位于加州伯克利的 NeuroFocus 被评为向全球客户提供基于脑波的营销研究的最大供应商，这些客户包括多个行业的《财富》(Fortune) 百强企业。尼尔森公司 (The Nielsen Company) 是 NeuroFocus 的一个战略投资方。
总部位于英国萨里的 Neuroco 将成为 NeuroFocus 在英国的运营基地，并将继续在英国和全欧洲扩大基于脑电图的市场研究的应用范围。Neuroco 的客户包括天空广播公司 (Sky Broadcasting) 和二十世纪福克斯 (20th century fox) 以及涉足汽车、包装消费品、饮料、休闲和零售行业的其它公司。
NeuroFocus 和 Neuroco 合作进行的基于脑电图的神经测试通过测量脑波来获得消费者的注意力、情感投入以及记忆留存水平。从这些数据中还可得出说服消费者、提升知名度以及创新的指标。由于许多大公司发现了可靠的神经测试所带来的独特战略优势，因此神经营销行业近年来得到了迅猛发展。
NeuroFocus 创始人兼首席执行官 A. K. Pradeep 博士表示：“此次合并标志着我们国际化发展的下一步计划，也表明全球商界已经认识到真正基于脑电图的神经测试是唯一值得信赖且具有科学依据的市场研究，它所提供的结果不仅可供行动参考，具有成本效益，而且拥有独一无二的精确度和相关性。我们曾放眼全球，寻找一个与我们一样以客户为中心，而且拥有与 NeuroFocus 同样严谨的科学态度、同样基于脑电图的脑波测试技术以及同样深厚的营销经验的公司。我们在 Neuroco 发现了这一切。”
神经学测试源自致力于大脑疾病和脑部环境研究的神经系统科学实验室的近期研究成果，它为企业提供了最精确、可靠而且能够指导行动的知识，即了解消费者大脑深层潜意识对刺激作出的真正反应是什么。
对消费者的这种了解至关重要，因为，神经科学研究表明，最初购买兴趣、购买意向和品牌忠诚度都是在潜意识层面上形成的。全脑脑电图测试和分析是最准确的神经学测试形式，因为脑电图传感器能够以每秒2000次的速度，从多达128个不同的脑部分区获取脑电波信号。
NeuroFocus 和 Neuroco 还利用眼动追踪和皮电反应测量相结合的方法，在消费者对产品设计和包装、品牌和营销产生何种反映以及零售品牌如何被认识等方面获得最全面的了解。
NeuroFocus 已凭借其专有技术和方法获得众多专利。在所有神经营销学公司中，该公司拥有最大的规范化数据库，其中包括数面向千种广告类别和产品的模板。
Neuroco 负责人 Thom Noble 担任 NeuroFocus Europe 董事总经理，他将带领 NeuroFocus 将业务拓展至英国和欧洲其他市场。Neuroco 科学部主管 Darren Bridges 将担任 NeuroFocus Europe 实验室业务部主管，负责协调 NeuroFocus 英国及欧洲实验室的科研活动。
Thom Noble 在评论此次收购时表示：“能够成为 NeuroFocus Europe 并为英国和欧洲客户带来世界神经营销学黄金标准令我们感到非常高兴，也很自豪。现在我们的重点是将我们对英国和欧洲市场独特需求的了解与 NeuroFocus 的知识、技术、专业技术人员和营销经验相融合，为我们的客户提供无与伦比的产品和服务，使他们能够凭借神经营销学在当前困难的经济环境中获得急需的经济收益。”
Neuroco 董事长 Peter Laybourne 将与 NeuroFocus Europe 合作，并继续担任 Fathom International Ltd. 领导职位，Fathom International Ltd. 是世界领先的品牌策划和研究公司之一。
英国地区神经营销学最早的开拓者、Neuroco 研发部主管 David Lewis 也将与 NeuroFocus Europe 合作。
NeuroFocus 和 Neuroco 都成立于2005年。
NeuroFocus 简介
NeuroFocus Inc. 是将神经系统科学知识和专长引入广告、营销、产品开发与包装以及娱乐领域的领导者。该公司将源自伯克利、麻省理工学院 (MIT)、哈佛大学 (Harvard) 以及希伯来大学 (Hebrew University) 在神经系统科学和营销方面的博士级学术专长与顶级业务管理和咨询经验相结合。
NeuroFocus 客户包括汽车、包装消费品、食品和饮料、金融服务、互联网、零售以及其它许多行业的《财富》(Fortune) 100强企业。娱乐业客户包括广播和有线电视以及电影业的大型公司。尼尔森公司 (The Nielsen Company) 是 NeuroFocus 的战略投资方。
Neuroco 简介
通过与领先的跨国公司客户合作，总部设在伦敦的 Neuroco 被公认为全球第一家利用脑电图技术的神经营销学机构。Neuroco 团队率先在广告、新产品开发构思和设计工作、包装开发、感官测试和购物者研究等众多研究领域采用了神经学和生物测试方法。
他们的业务涵盖产品设计研发、营销传播、客户/交易营销代理，其经验涉及快速消费品 (FMCG)、广播和娱乐，媒体和汽车业。
---------
附：neurofocus公司的网址
http://www.neurofocus.com/
加州伯克利2009年3月12日电 /美通社亚洲/ -- 迅速发展的神经营销学领域的世界领导者 NeuroFocus 宣布，该公司已经签署了一份收购 Neuroco 的协议。这一举动表明了该公司全球扩张的下一步计划，在此之前，NeuroFocus 已经在美国得到了迅速发展，并通过在日本和韩国等几个重要亚洲国家获得新的大客户拓展了自己在亚洲的业务。
NeuroFocus 和 Neuroco 均为未上市公司。此次收购的条款尚未公布。Neuroco 今后将作为NeuroFocus Europe 运营。
总部位于加州伯克利的 NeuroFocus 被评为向全球客户提供基于脑波的营销研究的最大供应商，这些客户包括多个行业的《财富》(Fortune) 百强企业。尼尔森公司 (The Nielsen Company) 是 NeuroFocus 的一个战略投资方。
总部位于英国萨里的 Neuroco 将成为 NeuroFocus 在英国的运营基地，并将继续在英国和全欧洲扩大基于脑电图的市场研究的应用范围。Neuroco 的客户包括天空广播公司 (Sky Broadcasting) 和二十世纪福克斯 (20th century fox) 以及涉足汽车、包装消费品、饮料、休闲和零售行业的其它公司。
NeuroFocus 和 Neuroco 合作进行的基于脑电图的神经测试通过测量脑波来获得消费者的注意力、情感投入以及记忆留存水平。从这些数据中还可得出说服消费者、提升知名度以及创新的指标。由于许多大公司发现了可靠的神经测试所带来的独特战略优势，因此神经营销行业近年来得到了迅猛发展。
NeuroFocus 创始人兼首席执行官 A. K. Pradeep 博士表示：“此次合并标志着我们国际化发展的下一步计划，也表明全球商界已经认识到真正基于脑电图的神经测试是唯一值得信赖且具有科学依据的市场研究，它所提供的结果不仅可供行动参考，具有成本效益，而且拥有独一无二的精确度和相关性。我们曾放眼全球，寻找一个与我们一样以客户为中心，而且拥有与 NeuroFocus 同样严谨的科学态度、同样基于脑电图的脑波测试技术以及同样深厚的营销经验的公司。我们在 Neuroco 发现了这一切。”
神经学测试源自致力于大脑疾病和脑部环境研究的神经系统科学实验室的近期研究成果，它为企业提供了最精确、可靠而且能够指导行动的知识，即了解消费者大脑深层潜意识对刺激作出的真正反应是什么。
对消费者的这种了解至关重要，因为，神经科学研究表明，最初购买兴趣、购买意向和品牌忠诚度都是在潜意识层面上形成的。全脑脑电图测试和分析是最准确的神经学测试形式，因为脑电图传感器能够以每秒2000次的速度，从多达128个不同的脑部分区获取脑电波信号。
NeuroFocus 和 Neuroco 还利用眼动追踪和皮电反应测量相结合的方法，在消费者对产品设计和包装、品牌和营销产生何种反映以及零售品牌如何被认识等方面获得最全面的了解。
NeuroFocus 已凭借其专有技术和方法获得众多专利。在所有神经营销学公司中，该公司拥有最大的规范化数据库，其中包括数面向千种广告类别和产品的模板。
Neuroco 负责人 Thom Noble 担任 NeuroFocus Europe 董事总经理，他将带领 NeuroFocus 将业务拓展至英国和欧洲其他市场。Neuroco 科学部主管 Darren Bridges 将担任 NeuroFocus Europe 实验室业务部主管，负责协调 NeuroFocus 英国及欧洲实验室的科研活动。
Thom Noble 在评论此次收购时表示：“能够成为 NeuroFocus Europe 并为英国和欧洲客户带来世界神经营销学黄金标准令我们感到非常高兴，也很自豪。现在我们的重点是将我们对英国和欧洲市场独特需求的了解与 NeuroFocus 的知识、技术、专业技术人员和营销经验相融合，为我们的客户提供无与伦比的产品和服务，使他们能够凭借神经营销学在当前困难的经济环境中获得急需的经济收益。”
Neuroco 董事长 Peter Laybourne 将与 NeuroFocus Europe 合作，并继续担任 Fathom International Ltd. 领导职位，Fathom International Ltd. 是世界领先的品牌策划和研究公司之一。
英国地区神经营销学最早的开拓者、Neuroco 研发部主管 David Lewis 也将与 NeuroFocus Europe 合作。
NeuroFocus 和 Neuroco 都成立于2005年。
NeuroFocus 简介
NeuroFocus Inc. 是将神经系统科学知识和专长引入广告、营销、产品开发与包装以及娱乐领域的领导者。该公司将源自伯克利、麻省理工学院 (MIT)、哈佛大学 (Harvard) 以及希伯来大学 (Hebrew University) 在神经系统科学和营销方面的博士级学术专长与顶级业务管理和咨询经验相结合。
NeuroFocus 客户包括汽车、包装消费品、食品和饮料、金融服务、互联网、零售以及其它许多行业的《财富》(Fortune) 100强企业。娱乐业客户包括广播和有线电视以及电影业的大型公司。尼尔森公司 (The Nielsen Company) 是 NeuroFocus 的战略投资方。
Neuroco 简介
通过与领先的跨国公司客户合作，总部设在伦敦的 Neuroco 被公认为全球第一家利用脑电图技术的神经营销学机构。Neuroco 团队率先在广告、新产品开发构思和设计工作、包装开发、感官测试和购物者研究等众多研究领域采用了神经学和生物测试方法。
他们的业务涵盖产品设计研发、营销传播、客户/交易营销代理，其经验涉及快速消费品 (FMCG)、广播和娱乐，媒体和汽车业。
---------
附：neurofocus公司的网址
http://www.neurofocus.com/
2009年7月21日星期二
Zack Lynch关于神经技术的书出版了
在美国的朋友有兴趣可以看一下。下面是他发来的内容。
"When I started reading this book, I thought Lynch's observations were rather hyperbolic. By the time I finished the book, I was stunned to realize that his points are not only rational but of urgent importance. Avoid reading this book at your peril."
- Vint Cerf, Chief Internet Evangelist, Google Inc.,
also known as the "Father of the Internet"
The Neuro Revolution
How Brain Science Is Changing Our World
Published by St. Martin's Press
History has already progressed through an agricultural revolution, an industrial revolution, and an information revolution. THE NEURO REVOLUTION: How Brain Science Is Changing Our World (St. Martin's Press) by Zack Lynch foretells a fast approaching fourth epoch that will yet again transform how humans live, work and play. Neurotechnology-new tools for both understanding and influencing our brains including brain imaging-is now being applied not only to breakthrough medicine but to almost every aspect of human endeavor, from financial markets to law enforcement to politics to advertising and marketing, artistic expression, warfare, and even to religious belief.
TNR CoverBy telling us the stories behind the brilliant people leading this worldwide revolution, taking us into their laboratories, boardrooms and courtrooms, Zack Lynch illuminates a unique, insider's glimpse into the startling future now arriving at our doorstep. The insights and revelations within THE NEURO REVOLUTION will foster wonder, debate, and in some cases consternation. Above all, though, they need to be understood by those who will be most affected-all of us.
THE NEURO REVOLUTION is the first book to provide a comprehensive view of the impact brain science will have on law, marketing, financial markets, education, national defense, religion, investing, healthcare, government and entertainment. Moreover, the book describes a new tool through which to view the future, Time's Telescope, which draws upon the history of technological revolutions to project into our common future.
ABOUT THE AUTHOR
ZACK LYNCH is the founder and executive director of the Neurotechnology Industry Organization, a global trade association representing companies involved in neuroscience, brain research centers and patient advocacy groups. He is also the co-founder of NeuroInsights, the world's leading market research firm covering the neurotechnology industry.
Please visit The Neuro Revolution website for more advance praise, information on book tour, or to purchase the book. To interview the author please contact Nadea Mina, Publicist, 646-307-5573, Nadea.Mina@StMartins.com.
The Neuro Revolution
How Brain Science is Changing Our World
By Zack Lynch with Byron Laursen
Publication Date: July 19, 2009
St. Martin's Press // Trade Hardcover
0-312-37862-9 // $25.99 // 256 pages
"When I started reading this book, I thought Lynch's observations were rather hyperbolic. By the time I finished the book, I was stunned to realize that his points are not only rational but of urgent importance. Avoid reading this book at your peril."
- Vint Cerf, Chief Internet Evangelist, Google Inc.,
also known as the "Father of the Internet"
The Neuro Revolution
How Brain Science Is Changing Our World
Published by St. Martin's Press
History has already progressed through an agricultural revolution, an industrial revolution, and an information revolution. THE NEURO REVOLUTION: How Brain Science Is Changing Our World (St. Martin's Press) by Zack Lynch foretells a fast approaching fourth epoch that will yet again transform how humans live, work and play. Neurotechnology-new tools for both understanding and influencing our brains including brain imaging-is now being applied not only to breakthrough medicine but to almost every aspect of human endeavor, from financial markets to law enforcement to politics to advertising and marketing, artistic expression, warfare, and even to religious belief.
TNR CoverBy telling us the stories behind the brilliant people leading this worldwide revolution, taking us into their laboratories, boardrooms and courtrooms, Zack Lynch illuminates a unique, insider's glimpse into the startling future now arriving at our doorstep. The insights and revelations within THE NEURO REVOLUTION will foster wonder, debate, and in some cases consternation. Above all, though, they need to be understood by those who will be most affected-all of us.
THE NEURO REVOLUTION is the first book to provide a comprehensive view of the impact brain science will have on law, marketing, financial markets, education, national defense, religion, investing, healthcare, government and entertainment. Moreover, the book describes a new tool through which to view the future, Time's Telescope, which draws upon the history of technological revolutions to project into our common future.
ABOUT THE AUTHOR
ZACK LYNCH is the founder and executive director of the Neurotechnology Industry Organization, a global trade association representing companies involved in neuroscience, brain research centers and patient advocacy groups. He is also the co-founder of NeuroInsights, the world's leading market research firm covering the neurotechnology industry.
Please visit The Neuro Revolution website for more advance praise, information on book tour, or to purchase the book. To interview the author please contact Nadea Mina, Publicist, 646-307-5573, Nadea.Mina@StMartins.com.
The Neuro Revolution
How Brain Science is Changing Our World
By Zack Lynch with Byron Laursen
Publication Date: July 19, 2009
St. Martin's Press // Trade Hardcover
0-312-37862-9 // $25.99 // 256 pages
2009年6月4日星期四
复数更新
- 美国研究者Thaler是决策研究与行为金融学的开山鼻祖，出版了nudge。该书是亚马逊上的畅销书，通过豆友了解到被美国政府所用。他个人成立了一家金融公司，倡导所谓behavioral portfolio（行为投资组合）。
- Neuroscan科学家Seed创办EEG+各种行为技术（例如眼动）的市场研究公司http://www.sandsresearch.com/
- 最后一刻07探讨了DARPA制造超级士兵的过程，DARPA意欲制造该类士兵希望通过动物实验来实现。方法是向amygdala注射某种物质，使得amygdala的size变大，fiber变粗壮。从而使得他们对恐惧或其他侵犯性表示具有更大更快速的反应倾向。
副作用：改变手性、头痛
研究人员提到中国、俄罗斯都在做相关的研究。
但是有一位外包生物科技公司雇佣的科学家为了让实验加快进行，额外雇佣了一位患有PTSD的归国士兵。谎称治疗PTSD，事实上利用该人类被试来测试超级士兵的神经增强药物效果。
导致了一系列意外。主人公与女主人公一起去解开这些意外，让违规的科学家被法律制裁。但DARPA的研究仍然在继续。。。。。
神经药物包括三种：认知增强药物、情感增强药物、感觉增强药物。
根据美国政府的一则报告，感觉增强药物会被首先使用（请见neurosociety群组中的文件）。
2009年5月5日星期二
中国今日的干细胞疗法
当奥巴马决定给美国干细胞研究松绑时，中国早就前行了一大步，已经将干细胞疗法应用到失明，脑瘫，脊髓损伤等领域，治疗效果也令人瞩目。
以一家生物科技公司Beike为 例，截至2009年2月，Beike使用脐带血干细胞注入法共治疗病人超过5087人次，涉及了运动失调，自闭症，肌萎缩侧索硬化症（ALS），脑外伤， 脑梗塞，脑出血，脑瘫，糖尿病，巴雷综合征，脑髓和脊髓损伤等被认为无法治疗的病症。Beike是如此之成功，它现在正在建造21500平方英尺的干细胞 储存库，并雇佣了哈佛大学等美国高校的教授。加利福尼亚的两个家庭甚至带着孩子飞往中国，治疗孩子的脑瘫。Beike的创始人Sean Hu博士满腔热情，他声称他的公司正在探索利用干细胞延长寿命的设想，使寿命能超过120年。
source: solidot
-------------
评价：
因为小布什的宗教信仰，美国在干细胞研究上落后中国了。这也可以看出中国没有一些伦理方面的顾忌反倒在一定程度上帮助了科研人员。长期来看，国内不会特别关注被试者、实验动物伦理这一块。这里有必要提到一个司法上的区别，民法是法律中针对公民的权利义务进行规定的一块，在我国，生命权是以婴儿出身开始算起的，而在美国，是以受精卵开始算起的。因而，正因为这一法律上的差别，中国在干细胞特别是胚胎干细胞甚至是克隆技术方面的研究的司法风险要比美国小。
以一家生物科技公司Beike为 例，截至2009年2月，Beike使用脐带血干细胞注入法共治疗病人超过5087人次，涉及了运动失调，自闭症，肌萎缩侧索硬化症（ALS），脑外伤， 脑梗塞，脑出血，脑瘫，糖尿病，巴雷综合征，脑髓和脊髓损伤等被认为无法治疗的病症。Beike是如此之成功，它现在正在建造21500平方英尺的干细胞 储存库，并雇佣了哈佛大学等美国高校的教授。加利福尼亚的两个家庭甚至带着孩子飞往中国，治疗孩子的脑瘫。Beike的创始人Sean Hu博士满腔热情，他声称他的公司正在探索利用干细胞延长寿命的设想，使寿命能超过120年。
source: solidot
-------------
评价：
因为小布什的宗教信仰，美国在干细胞研究上落后中国了。这也可以看出中国没有一些伦理方面的顾忌反倒在一定程度上帮助了科研人员。长期来看，国内不会特别关注被试者、实验动物伦理这一块。这里有必要提到一个司法上的区别，民法是法律中针对公民的权利义务进行规定的一块，在我国，生命权是以婴儿出身开始算起的，而在美国，是以受精卵开始算起的。因而，正因为这一法律上的差别，中国在干细胞特别是胚胎干细胞甚至是克隆技术方面的研究的司法风险要比美国小。
2009年5月3日星期日
2岁女孩成为门萨俱乐部最年轻会员
门萨俱乐部是一个国际组织，其最大特色是以智商为唯一入会标准。据说来自中国大陆的会员有40余人，其中比较知名的是杨冰阳（Ayawawa ）。现在一名2006年出生的英国女孩Elise Tan-Roberts成为门萨俱乐部最年轻会员(BBC中文)。
2岁的Elise居住在伦敦北部，熟知26个英文字母，能用西班牙语从1数到10，并能叫出各种三角形的名称，说出35国首都名称，她的的智商指数高达 156。Elise身上有着英格兰、马来亚、中国、尼日利亚和塞拉利昂等多国血统，5个月大就说出了第一个词，8个半月就开始走路。她的父亲说，“我们的 主要目标是确保她以超前的步伐学习...但她只是一个孩子，我们希望她能过得快乐。”
source: solidot
2岁的Elise居住在伦敦北部，熟知26个英文字母，能用西班牙语从1数到10，并能叫出各种三角形的名称，说出35国首都名称，她的的智商指数高达 156。Elise身上有着英格兰、马来亚、中国、尼日利亚和塞拉利昂等多国血统，5个月大就说出了第一个词，8个半月就开始走路。她的父亲说，“我们的 主要目标是确保她以超前的步伐学习...但她只是一个孩子，我们希望她能过得快乐。”
source: solidot
2009年4月29日星期三
For Alzheimer's Disease, Surveyed Neurologists Identify a Therapy's Effect on Cognitive Decline as the Attribute That Most Influences Their Prescribin
药业咨询公司Decision Resources对神经病学家访问发现了他们对阿兹海默症开药时的标准，以及符合这种标准的药物组合。
The Combination of Bapineuzumab and Donepezil Will Earn Decision Resources' Gold Standard Status for the Indication in 2012, According to a New Report from Decision Resources
WALTHAM, Mass., April 29 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that surveyed neurologists identify a therapy's effect on cognitive decline as the attribute that most influences their prescribing decisions in mild to moderate Alzheimer's disease. As potential disease-modifying drugs, interviewed thought leaders indicate that Elan/Wyeth's bapineuzumab, Eli Lilly's solanezumab and semagacestat, Medivation/Pfizer's Dimebon and Baxter Healthcare's Gammagard all have advantages in this attribute over donepezil (Eisai/Pfizer's Aricept, Bracco's Memac), the sales-leading agent in the market.
...
more on biomed
Neurocrine Biosciences Announces Conference Call and Webcast to Present First Quarter 2009 Financial Results
一家神经制药公司要召开财务新闻发布会，这个就不多说了
source: biomed
source: biomed
Conference Call and Webcast Scheduled for Wednesday, May 6, 2009
SAN DIEGO, April 29 /PRNewswire-FirstCall/ -- Neurocrine Biosciences, Inc. (Nasdaq: NBIX) announced today that the Company will report its first quarter 2009 financial results after the Nasdaq market closes on Tuesday, May 5, 2009. Neurocrine will then host a live conference call and webcast to discuss its financial results and provide a Company update Wednesday morning, May 6, 2009 at 8:30 a.m. Eastern Daylight Time (5:30 a.m. Pacific Daylight Time).
Participants can access the live conference call by dialing 1-800-895-0198, (US) or 785-424-1053 (International) using the conference ID: 7NEURO. The call can also be accessed via the webcast through the Company's website at http://www.neurocrine.com
If you are unable to attend the Webcast and would like further information on this announcement please contact the Investor Relations Department at Neurocrine Biosciences at (858) 617-7600. A replay of the Conference Call will be available approximately one hour after the conclusion of the call by dialing 1-800-688-7339 (US) or 402-220-1347 (International) using the conference ID: 7NEURO. The call will be archived for two weeks.
Neurocrine Biosciences, Inc. is a biopharmaceutical company focused on neurological and endocrine diseases and disorders.
Adults 'Facing' ADHD: ADHD Allies™ Offers Unique Online Community for Adults with ADHD on New Facebook® Page
Facebook上患ADHD成年人的群组。
Titusville, NJ (April 22, 2009) — Although Attention Deficit Hyperactivity Disorder (ADHD) is a condition commonly thought of as only affecting children, for nearly 9 million adults in the United States, ADHD is very much a reality. According to the National Institutes of Mental Health, adults with ADHD often struggle with getting organized, sticking to a job, remembering or keeping appointments and being productive.
more on Johnson & Johnson's
Titusville, NJ (April 22, 2009) — Although Attention Deficit Hyperactivity Disorder (ADHD) is a condition commonly thought of as only affecting children, for nearly 9 million adults in the United States, ADHD is very much a reality. According to the National Institutes of Mental Health, adults with ADHD often struggle with getting organized, sticking to a job, remembering or keeping appointments and being productive.
more on Johnson & Johnson's
2009年4月28日星期二
心理画像（psychological profiling）
最近发现美剧的新大陆，通过他们认识了本来非常陌生但是却有很大应用价值的领域-心理画像。
追看的两部美剧（lie to me不算）将这部分描写得活灵活现。他们是《criminal minds》和《the mentalist》。后面一部没有前面一部那么有名，但其中主角也是借助行为证据分析（例如照片中青春期女儿坐在父亲大腿上推断出两人关系不一般）来达到探案的效果。
criminal minds的真实机构是FBI的bahavior analysis unit（BAU），该机构的倡导者之一是John Douglas。当然，对于心理学应用感兴趣的人可能会觉得在警察机构里面做不见得待遇就好，毕竟公务员在美国并不是profitable的职业。其实我在网页上乱搜的结果发现美国已经有专门服务于司法的公司了，而且它的基础是行为科学，领域名字是forensic behavioral science。
前不久在网上发现一家为BAU服务的公司，叫Academy group Inc.。它是有BAU前任员工创建的，ms客户还有很多财富500强的公司。
追看的两部美剧（lie to me不算）将这部分描写得活灵活现。他们是《criminal minds》和《the mentalist》。后面一部没有前面一部那么有名，但其中主角也是借助行为证据分析（例如照片中青春期女儿坐在父亲大腿上推断出两人关系不一般）来达到探案的效果。
criminal minds的真实机构是FBI的bahavior analysis unit（BAU），该机构的倡导者之一是John Douglas。当然，对于心理学应用感兴趣的人可能会觉得在警察机构里面做不见得待遇就好，毕竟公务员在美国并不是profitable的职业。其实我在网页上乱搜的结果发现美国已经有专门服务于司法的公司了，而且它的基础是行为科学，领域名字是forensic behavioral science。
前不久在网上发现一家为BAU服务的公司，叫Academy group Inc.。它是有BAU前任员工创建的，ms客户还有很多财富500强的公司。
Brain fitness authority(so-called)
今天找到的一家由神经科学家Elkhonon Goldberg和曾在麦肯锡做过的Alvaro Fernandez共同创立的市场调研公司，和neuroinsight几乎一模一样的宣言（neurotech market authority）。
瞧瞧这种模式，我们落后了多少。现在只有做代理的份了。
从它的客户名单上，我们可以看到一些端倪，包括我关注的posit science都是它的客户。
瞧瞧这种模式，我们落后了多少。现在只有做代理的份了。
从它的客户名单上，我们可以看到一些端倪，包括我关注的posit science都是它的客户。
Below you have a partial list of clients:
Advanced Brain Technologies
AARP
Aberdare Ventures
AKM Holdings
Aspyr Media, Inc
BCM technologies
Behavioral Science Technology
Belmont Village Senior Living
BerCon Ltd
BIDMC-Harvard Medical Center
Binnacle Capital
Brain Resource Company
Brookdale Senior Living
Case Western Reserve University
Club One, Inc.
Cogmed
CogniFit
CogState
Dakim
Ericsson
Ernst & Young Advisory
Easter Seals
Harvard Medical School
International Masters Publishers
Johnson & Johnson Development Corporation
Kaiser Permanente
MaRS Discovery District
Memorial Hospital Health System
Memphis City Schools
Merit Entertainment
Mindmedi Clinic
National Academy Child Development
National Research Council of Canada
Navon
NeuroCare Network
New York Public Library
NovaVision
OptumHealth
Oregon Center for Applied Science
Osmium Partners
Peninsula Jewish Community Center
Posit Science
Sunrise Senior Living
University of Texas at Austin
University of Michigan
US Army Research Lab
Scientific Learning
Scientific Brain Training
Sutter Health Partners
VibrantBrains
2009年4月27日星期一
收费信息一则
Posit Science Adds $5.6M For Brain Power
With plenty of venture interest in companies offering brain fitness technology, Posit Science Corp. has raised $5.6 million in insider Series C funding, company President and Chief Executive Steven Aldrich said.
2009年4月21日星期二
NeuroScience Pharmaceuticals Launches in Research Triangle Park
NeuroScience Pharmaceuticals Inc. has been launched in Research Triangle Park with the help of a North Carolina Biotechnology Center loan. The pharmaceutical company is developing treatments for brain disorders, utilizing technology licensed from Duke University and Durham Veterans Affairs Medical Center (VA).
Dr. Gabriel Cipau, President and CEO of the new clinical-stage company, said it will be focused on the development of neurosteroid drugs. Neurosteroids are potent brain substances that play a role in controlling anxiety and depression. NeuroScience’s lead product, Pregnenolone, is being tested for the treatment of schizophrenia in two fully funded Phase II clinical trials. Each study will involve 88 patients and enrollment is expected to start in the next two months.
“Multiple characteristics of Pregnenolone support its potential efficacy for the treatment of cognitive and negative symptoms in schizophrenia. Pregnenolone has multiple mechanisms of action supported by an extensive preclinical literature and emerging clinical data. Phase I clinical trials have indicated that Pregnenolone has the potential to effectively address schizophrenia symptoms with a favorable side effect profile”, said Dr. Cipau. The trial results were announced in a recent publication: Marx CE et al. Proof-of-Concept Trial with the Neurosteroid Pregnenolone Targeting Cognitive and Negative Symptoms in Schizophrenia, Neuropsychopharmacology (2009), 1-19.
“We look forward to efforts by Neuroscience Pharmaceuticals to bring this promising compound through the development process and, ultimately, to the clinic,” said Dr. Brandy Salmon, Associate Director, The Office of Licensing and Ventures at Duke University. “This new company will focus on advancing compounds for the treatment of various psychiatric and neurological disorders in which patients are currently underserved by available therapies.”
Dr. Cipau said he expects NeuroScience to pursue other potential therapeutic applications for Pregnenolone, including cognitive impairment, Alzheimer's disease, post-traumatic stress disorder, depression, and addiction. The future product pipeline also includes a variety of delivery mechanisms and second generation neurosteroid compounds.
Dr. Cipau is a former Wellcome PLC executive and was CEO of several pharmaceutical and biotechnology companies including Nippon Wellcome, Catalytica Pharmaceuticals, Copley Pharmaceuticals, Biolex and PhaseBio.
Dr. Christine Marx serves as an unpaid scientific advisor/board member. She is an Associate Professor of Biological Psychiatry at Duke University Medical Center and the Durham VA Medical Center and directs the Interventions and Metabolomics Core of the VA Mid-Atlantic Mental Illness Research, Education, and Clinical Center. Her efforts are at the leading edge of research investigating neurosteroids.
The NC Biotechnology Center approved a $50,000 low-interest Company Inception Loan to NeuroScience – the latest in a series of loans made by the Biotechnology Center to support start-up biotech firms.
“NeuroScience Pharmaceuticals represents the kind of investment in our state’s future that has been the Biotechnology Center’s hallmark for nearly 25 years,” said John Richert, Vice President of business and technology development for the Biotechnology Center. “This inception loan helps pay for basic activities related to the formation of the company, making it possible for NeuroScience to find the necessary funding for Phase III clinical trials from investors. And if the company grows as we anticipate, it will add to our increasingly important statewide base of more than 500 biotech companies employing more than 56,000 people.”
NeuroScience Pharmaceuticals is currently seeking series A investment to continue the clinical development of the lead product, Pregnenolone, develop new forms of delivery and extend the use to other indications. The company is also seeking partners for clinical development and development of new delivery technologies.
Contacts:
NeuroScience Pharmaceuticals Inc.
Gabriel Cipau, Ph.D., President & CEO
Phone: 919-455-7775 Fax: 919-270-2990
gcipau@neurosciencepharma.com
www.NeuroSciencePharma.com
source: chron.com
Gabriel Cipau, Ph.D., President & CEO
Phone: 919-455-7775 Fax: 919-270-2990
gcipau@neurosciencepharma.com
www.NeuroSciencePharma.com
source: chron.com
2009年4月19日星期日
JMG：一种大脑基因受损可形成自闭症（转载）
近日，美国研究人员宣称，与大脑功能建立连接的一种基因可能对于形成自闭症具有重要意义。
一种叫做“contactin 4”基因的瓦解损失将停止其正常工作，并使大脑正常的工作网络中断。这项研究报告发表在《医学遗传学期刊》（Journal of Medical Genetics）上。负责此项研究的纽约州立大学石溪分校伊莱·哈奇韦尔博士称，儿童体内出现三组contactin 4基因瓦解或者三组中有一组瓦解，均将导致2.5%患自闭症的几率。
哈 奇韦尔在一次电话采访中说，“通常人们都错误地认为自闭症是由于后天因素导致的，并没有想到这种病症会与遗传基因突变有联系。”他表示将这项研究添加到了 自闭症潜在测试列表之中，或许将有助于对泛自闭症的治疗。泛自闭症是一种会影响儿童多方面功能的发育障碍，此障碍特征是沟通技巧迟缓、社交互动和思维想像 能力出现障碍。
哈奇韦尔的研究小组对来自81个家庭的92位泛自闭症患者与560位无自闭症人群进行对比，他们做出一个完整的基因组分 析，观看完整的DNA图，结果发现其中有三位患者的contactin 4基因不完整，其DNA片断出现瓦解受损。这些患者都是从未患自闭症的父亲那里继承该基因，患者表现出严重的社交障碍、发育延迟，甚至出现智力迟缓。他强 调称，许多人认为自闭症患者人群是一个小数目，实际上全球有数百万自闭症患者。美国疾病控制和预防中心评估每150个儿童中就有1个自闭症患者，或者是相 关的亚斯柏格症患者（该病症经常表现为轻微的社交笨拙）。
Contactin 4基因是一个发育状态中的轴突，轴突一般是传导远离神经元的神经纤维突，它们可以形成一个长线排列，彼此神经元之 间进行连接。哈奇韦尔指出，这种基因突变是出现于婴儿出生时。一些病例中，儿童患者有自闭症而其父亲却是正常的，但实际上自闭症始终与基因有直接关系，时 常有一些病例显示自己是正常的，但是他们的后代却患有严重自闭症。这可能是父亲在儿童时期曾有轻微的亚斯柏格症或相应的某些症状，但他却未曾进行诊断。目 前，美国许多成年人在他儿童时期很少去医院就诊检查是否患有自闭症，而他们的父辈接受诊断的几率则更低。
这是一个富有争议的话题，一些专 家称自闭症和相关的疾病患者是近年内人数骤增，而另一些专家表示目前没有证据足以证实以上结论。哈奇韦尔说，“我个人观点认为自闭症并不是近年来才变得很 普遍，现今如果家长意识到孩子在学习方面存在问题，便会尽可能地诊断为自闭症患者，以寻找学校多方面的教育帮助。”
据了解，哈奇韦尔帮助建立了人群诊断生物科技公司，以开展症状前DNA分析和早期侦查探测自闭症、阿茨海默症、帕金森氏症、糖尿病和其他遗传疾病。（生物谷Bioon.com）
生物谷推荐原始出处：
Journal of Medical Genetics 2009;46:176-182
Disruption of contactin 4 in three subjects with autism spectrum disorder
J Roohi1, C Montagna2, D H Tegay3,4, L E Palmer5, C DeVincent3, J C Pomeroy3, S L Christian6, N Nowak7 and E Hatchwell1,8
1 Department of Genetics, Stony Brook University, Stony Brook, New York, USA
2 Department of Pathology and Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York, USA
3 Department of Pediatrics, Stony Brook University Medical Center, Stony Brook, New York, USA
4 Department of Medicine & Medical Genetics, New York College of Osteopathic Medicine, Old Westbury, New York, USA
5 Department of Microbiology, Stony Brook University, Stony Brook, New York, USA
6 Department of Human Genetics, The University of Chicago, Chicago, Illinois, USA
7 Department of Cancer Prevention and Population Sciences, RPCI and New York State Center of Excellence in Bioinformatics and Life Sciences, University at Buffalo, New York, USA
8 Department of Pathology, Stony Brook University, Stony Brook, New York, USA
Correspondence to:
Dr E Hatchwell, Department of Pathology, BST-9, SUNY at Stony Brook, Stony Brook, NY 11794-8691, USA;
ABSTRACT
Background: Autism spectrum disorder (ASD) is a developmental disorder of the central nervous system of largely unknown aetiology. The prevalence of the syndrome underscores the need for biological markers and a clearer understanding of pathogenesis. For these reasons, a genetic study of idiopathic ASD was undertaken.
Methods and results: Array based comparative genomic hybridisation identified a paternally inherited chromosome 3 copy number variation (CNV) in three subjects: a deletion in two siblings and a duplication in a third, unrelated individual. These variations were fluorescence in situ hybridisation (FISH) validated and the end points further delineated using a custom fine tiling oligonucleotide array. Polymerase chain reaction (PCR) products unique to the rearrangements were amplified and sequence analysis revealed the variations to have resulted from Alu Y mediated unequal recombinations interrupting contactin 4 (CNTN4).
Conclusion: CNTN4 plays an essential role in the formation, maintenance, and plasticity of neuronal networks. Disruption of this gene is known to cause developmental delay and mental retardation. This report suggests that mutations affecting CNTN4 function may be relevant to ASD pathogenesis.
一种叫做“contactin 4”基因的瓦解损失将停止其正常工作，并使大脑正常的工作网络中断。这项研究报告发表在《医学遗传学期刊》（Journal of Medical Genetics）上。负责此项研究的纽约州立大学石溪分校伊莱·哈奇韦尔博士称，儿童体内出现三组contactin 4基因瓦解或者三组中有一组瓦解，均将导致2.5%患自闭症的几率。
哈 奇韦尔在一次电话采访中说，“通常人们都错误地认为自闭症是由于后天因素导致的，并没有想到这种病症会与遗传基因突变有联系。”他表示将这项研究添加到了 自闭症潜在测试列表之中，或许将有助于对泛自闭症的治疗。泛自闭症是一种会影响儿童多方面功能的发育障碍，此障碍特征是沟通技巧迟缓、社交互动和思维想像 能力出现障碍。
哈奇韦尔的研究小组对来自81个家庭的92位泛自闭症患者与560位无自闭症人群进行对比，他们做出一个完整的基因组分 析，观看完整的DNA图，结果发现其中有三位患者的contactin 4基因不完整，其DNA片断出现瓦解受损。这些患者都是从未患自闭症的父亲那里继承该基因，患者表现出严重的社交障碍、发育延迟，甚至出现智力迟缓。他强 调称，许多人认为自闭症患者人群是一个小数目，实际上全球有数百万自闭症患者。美国疾病控制和预防中心评估每150个儿童中就有1个自闭症患者，或者是相 关的亚斯柏格症患者（该病症经常表现为轻微的社交笨拙）。
Contactin 4基因是一个发育状态中的轴突，轴突一般是传导远离神经元的神经纤维突，它们可以形成一个长线排列，彼此神经元之 间进行连接。哈奇韦尔指出，这种基因突变是出现于婴儿出生时。一些病例中，儿童患者有自闭症而其父亲却是正常的，但实际上自闭症始终与基因有直接关系，时 常有一些病例显示自己是正常的，但是他们的后代却患有严重自闭症。这可能是父亲在儿童时期曾有轻微的亚斯柏格症或相应的某些症状，但他却未曾进行诊断。目 前，美国许多成年人在他儿童时期很少去医院就诊检查是否患有自闭症，而他们的父辈接受诊断的几率则更低。
这是一个富有争议的话题，一些专 家称自闭症和相关的疾病患者是近年内人数骤增，而另一些专家表示目前没有证据足以证实以上结论。哈奇韦尔说，“我个人观点认为自闭症并不是近年来才变得很 普遍，现今如果家长意识到孩子在学习方面存在问题，便会尽可能地诊断为自闭症患者，以寻找学校多方面的教育帮助。”
据了解，哈奇韦尔帮助建立了人群诊断生物科技公司，以开展症状前DNA分析和早期侦查探测自闭症、阿茨海默症、帕金森氏症、糖尿病和其他遗传疾病。（生物谷Bioon.com）
生物谷推荐原始出处：
Journal of Medical Genetics 2009;46:176-182
Disruption of contactin 4 in three subjects with autism spectrum disorder
J Roohi1, C Montagna2, D H Tegay3,4, L E Palmer5, C DeVincent3, J C Pomeroy3, S L Christian6, N Nowak7 and E Hatchwell1,8
1 Department of Genetics, Stony Brook University, Stony Brook, New York, USA
2 Department of Pathology and Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York, USA
3 Department of Pediatrics, Stony Brook University Medical Center, Stony Brook, New York, USA
4 Department of Medicine & Medical Genetics, New York College of Osteopathic Medicine, Old Westbury, New York, USA
5 Department of Microbiology, Stony Brook University, Stony Brook, New York, USA
6 Department of Human Genetics, The University of Chicago, Chicago, Illinois, USA
7 Department of Cancer Prevention and Population Sciences, RPCI and New York State Center of Excellence in Bioinformatics and Life Sciences, University at Buffalo, New York, USA
8 Department of Pathology, Stony Brook University, Stony Brook, New York, USA
Correspondence to:
Dr E Hatchwell, Department of Pathology, BST-9, SUNY at Stony Brook, Stony Brook, NY 11794-8691, USA;
ABSTRACT
Background: Autism spectrum disorder (ASD) is a developmental disorder of the central nervous system of largely unknown aetiology. The prevalence of the syndrome underscores the need for biological markers and a clearer understanding of pathogenesis. For these reasons, a genetic study of idiopathic ASD was undertaken.
Methods and results: Array based comparative genomic hybridisation identified a paternally inherited chromosome 3 copy number variation (CNV) in three subjects: a deletion in two siblings and a duplication in a third, unrelated individual. These variations were fluorescence in situ hybridisation (FISH) validated and the end points further delineated using a custom fine tiling oligonucleotide array. Polymerase chain reaction (PCR) products unique to the rearrangements were amplified and sequence analysis revealed the variations to have resulted from Alu Y mediated unequal recombinations interrupting contactin 4 (CNTN4).
Conclusion: CNTN4 plays an essential role in the formation, maintenance, and plasticity of neuronal networks. Disruption of this gene is known to cause developmental delay and mental retardation. This report suggests that mutations affecting CNTN4 function may be relevant to ASD pathogenesis.
2009年4月14日星期二
认知测验提供商-剑桥认知公司
from Cambridge Cognition Ltd.
基于剑桥大学，产品是cantab
其临床产品被辉瑞、阿斯利康、葛兰素史克使用，它还是很牛的嘛
http://www.cantab.com/camcog/default.asp
下面这张图是这个产品里面所有的认知测验。
产品介绍的ppt
基于剑桥大学，产品是cantab
其临床产品被辉瑞、阿斯利康、葛兰素史克使用，它还是很牛的嘛
http://www.cantab.com/camcog/default.asp
下面这张图是这个产品里面所有的认知测验。
产品介绍的ppt
2009年4月8日星期三
Humanitas Approved by American Psychological Association (APA) as Provider of Continuing Education Credits to Psychologists
First Offering to Serve Health Professionals, Instructors and Counselors
SILVER SPRING, Md., April 8 /PRNewswire/ -- Today the American Psychological Association (APA) notified Humanitas, Inc., that the woman-owned small business met the stringent criteria to offer continuing education credit hours to psychologists who attend and complete Humanitas-sponsored educational programs.
......
more on biomedicine.org
ms这家公司是给临床心理医生做继续教育培训的
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