2009年3月16日星期一

读脑研究一篇

Current Biology:由fMRI信号预测空间记忆

http://www.bbioo.com/Article/2009/23400.htm

该文章所用的技术是虚拟现实加上fMRI的技术。近来已经成为主流。而且更牛的技术是还需要与脑电仪(EEG、ERP)结合。该文章比较牛,因为对于心理 学常用的外部任务(实验性分离,即通过不同的行为任务来区分心理过程或者人的意识,可以参看遗忘症患者H.M.的研究,顺便纪念一下前不久去世的他),它 加以控制,纯粹从fMRI海马信号做出了预测,确实具有测谎和神经营销学的意义。当然,伦理肯定不谈了。不过该文的意义还是在精神疾病方面,因为海马组织 的亚区可能起的功能是不一致的。最后我的疑问是:仅仅通过海马信号就预测对了?枕叶视觉区有一个where-what通路,那里应该也可以做到这一点啊?

附(还有我觉得重要的结论,用红色划出了):
Summary
The hippocampus underpins our ability to navigate, to form and recollect memories, and to imagine future experiences. How activity across millions of hippocampal neurons supports these functions is a fundamental question in neuroscience, wherein the size, sparseness, and organization of the hippocampal neural code are debated.Here, by using multivariate pattern classification and high spatial resolution functional MRI, we decoded activity across the population of neurons in the human medial temporal lobe while participants navigated in a virtual reality environment. Remarkably, we could accurately predict the position of an individual within this environment solely from the pattern of activity in his hippocampus even when visual input and task were held constant. Moreover, we observed a dissociation between responses in the hippocampus and parahippocampal gyrus, suggesting that they play differing roles in navigation.These results show that highly abstracted representations of space are expressed in the human hippocampus. Furthermore, our findings have implications for understanding the hippocampal population code and suggest that, contrary to current consensus, neuronal ensembles representing place memories must be large and have an anisotropic structure.

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